P2.01-068 Analysis of Epithelial-Stromal Interactions and their Relevance to Lung Cancer
نویسندگان
چکیده
منابع مشابه
EVALUATION OF SERUM IM MUNOGLOBULINS AND THEIR RELEVANCE TO CHRONIC LUNG DISEASE IN MUSTARD GAS VICTINIS
Despite the fact that 8 years has elapsed since the end of the imposed war, chemically injured victims are still suffering from various long-term complications, most of them respiratory in nature. The progressive nature of respiratory problems in these patients suggests that the immune system must be involved to Initiate a cascade which ends up causing lung injuries. To evaluate this, humo...
متن کاملAnalysis of epithelial mesenchymal transition markers in breast cancer cells in response to stromal cell-derived factor 1
Introduction: Metastasis is the main cause of cancer death; however, the underlying mechanisms of metastasis are largely unknown. The chemokine of stromal cell-derived factor 1 (SDF1) and the process of epithelial mesenchymal transition (EMT), both have been declared as important factors to promote cancer metastasis; however, Conspicuously, the relation between them has not been recognized well...
متن کاملStromal-epithelial interactions in the progression of ovarian cancer: influence and source of tumor stromal cells.
Stromal cells are essential for the progression of many cancers including ovarian tumors. Stromal cell-epithelial cell interactions are important for tumor development, growth, angiogenesis, and metastasis. In the current study, the effects of normal ovarian bovine stromal cells on ovarian tumor progression was investigated. The hypothesis tested is that ovarian stromal cells will alter the ons...
متن کاملMolecular portraits of epithelial, mesenchymal, and hybrid States in lung adenocarcinoma and their relevance to survival.
Epithelial-to-mesenchymal transition (EMT) is a key process associated with tumor progression and metastasis. To define molecular features associated with EMT states, we undertook an integrative approach combining mRNA, miRNA, DNA methylation, and proteomic profiles of 38 cell populations representative of the genomic heterogeneity in lung adenocarcinoma. The resulting data were integrated with...
متن کاملFGFR2 isoforms support epithelial-stromal interactions in thyroid cancer progression.
Alternate splicing yields two distinct isoforms of the fibroblast growth factor (FGF) receptor FGFR2-IIIb and FGFR2-IIIc varying their extracellular structure in human thyroid cancer, in which FGFR expression is commonly dysregulated. In this study, we characterized the function of these variants in modulating thyroid cancer behavior. Enforced expression of either FGFR2-IIIb or FGFR2-IIIc in th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2017
ISSN: 1556-0864
DOI: 10.1016/j.jtho.2016.11.1120